An elderly wanderer, a sexy young girl running away from home and a folk singer looking for stardom hitch-hike their way cross-country, trying to get to California.
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Mexican beauty Camilla hopes to rise above her station by marrying a wealthy American. That is complicated by meeting Arturo Bandini, a first-generation Italian hoping to land a writing career and a blue-eyed blonde on his arm.
While doing a friend a favor and searching for a runaway teenager, a police detective stumbles upon a bizarre band of criminals about to pull off a bank robbery.
Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
Kathy leaves the newspaper business to marry homicide detective Bill, but is frustrated by his lack of ambition and the banality of life in the suburbs. Her drive to advance Bill's career soon takes her down a dangerous path.
In 1970s Hollywood, Detective Philip Marlowe tries to help a friend who is accused of murdering his wife.
After living abroad, Lana returns to the United States, and finds that her uncle is a reclusive vagabond with psychic wounds from the Vietnam War.